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    tlf-1 TATA box-binding protein-like 1 [ Caenorhabditis elegans ]

    Gene ID: 172676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tlf-1
    Official Full Name
    TATA box-binding protein-like 1
    Primary source
    WormBase:WBGene00006577
    Locus tag
    CELE_F39H11.2
    See related
    AllianceGenome:WB:WBGene00006577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable general transcription initiation factor activity. Involved in embryo development; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including germ line. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tlf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (8697504..8701973, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene putative ATP synthase subunit g 1, mitochondrial Neighboring gene Proteasome subunit beta Neighboring gene Craniofacial development protein 1 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene silencing in Caenorhabditis elegans by transitive RNA interference. Alder MN, et al. RNA, 2003 Jan. PMID 12554873, Free PMC Article
    2. TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans. Dantonel JC, et al. Mol Cell, 2000 Sep. PMID 11030350
    3. The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Kaltenbach L, et al. Mol Cell, 2000 Sep. PMID 11030349
    4. Analysis of the role of Caenorhabditis elegans GC-AG introns in regulated splicing. Farrer T, et al. Nucleic Acids Res, 2002 Aug 1. PMID 12140320, Free PMC Article
    5. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. Kniazeva M, et al. PLoS Biol, 2004 Sep. PMID 15340492, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development
      Title: An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TATA box-binding protein-like 1
    NP_001122474.1
    • Confirmed by transcript evidence
    NP_492356.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8697504..8701973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059955.7 → NP_492356.1  TATA box-binding protein-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC52
      Conserved Domains (2) summary
      PLN00062
      Location:265 → 441
      PLN00062; TATA-box-binding protein; Provisional
      cd04517
      Location:263 → 439
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    2. NM_001129002.4 → NP_001122474.1  TATA box-binding protein-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6P4, G5EC52, Q9XZQ7
      Conserved Domains (2) summary
      cd04517
      Location:266 → 442
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
      cl41729
      Location:183 → 217
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2D6P4.1

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