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    unc-61 Septin;Septin-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-61
    Official Full Name
    Septin;Septin-type G domain-containing protein
    Primary source
    WormBase:WBGene00006795
    Locus tag
    CELE_Y50E8A.4
    See related
    AllianceGenome:WB:WBGene00006795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Located in cleavage furrow and midbody. Is expressed in anterior distal tip cell; nerve ring; posterior distal tip cell; and ventral cord neurons. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including SEPTIN11 (septin 11) and SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-61 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (14731064..14734237, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Major sperm protein Neighboring gene Ig-like domain-containing protein Neighboring gene Protein quiver Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans septins contribute to the development and structure of the oogenic germline. Perry JA, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 37265173, Free PMC Article
    2. The C. elegans septin genes, unc-59 and unc-61, are required for normal postembryonic cytokineses and morphogenesis but have no essential function in embryogenesis. Nguyen TQ, et al. J Cell Sci, 2000 Nov. PMID 11034910
    3. A role for septins in cellular and axonal migration in C. elegans. Finger FP, et al. Dev Biol, 2003 Sep 1. PMID 12941631
    4. The Caenorhabditis elegans septin complex is nonpolar. John CM, et al. EMBO J, 2007 Jul 25. PMID 17599066, Free PMC Article
    5. Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. Maddox AS, et al. Dev Cell, 2007 May. PMID 17488632

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In unc-61 mutants, 6% of the M2 distal ends are defective and the pharynx is slightly twisted.
      Title: A genetic analysis of axon guidance in the C elegans pharynx.
    2. may be generally required for developmental migrations and pathfinding
      Title: A role for septins in cellular and axonal migration in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Septin;Septin-type G domain-containing protein
    NP_001041198.2
    • Confirmed by transcript evidence
    NP_506638.2
    • Confirmed by transcript evidence
    NP_872156.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14731064..14734237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182356.5 → NP_872156.2  Septin-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872156.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4C9
      Conserved Domains (2) summary
      cd01850
      Location:165 → 434
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:380 → 530
      DUF5401; Family of unknown function (DUF5401)

    2. NM_001047733.5 → NP_001041198.2  Septin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041198.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q25AR8
      Conserved Domains (2) summary
      cd01850
      Location:96 → 365
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:311 → 465
      DUF5401; Family of unknown function (DUF5401)

    3. NM_074237.8 → NP_506638.2  Septin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506638.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U277
      Conserved Domains (2) summary
      cd01850
      Location:96 → 365
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:311 → 461
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein
    Heading Accession and Version

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