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    lmbr-1 LIMR family protein R05D3.2 [ Caenorhabditis elegans ]

    Gene ID: 176182, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmbr-1
    Official Full Name
    LIMR family protein R05D3.2
    Primary source
    WormBase:WBGene00019877
    Locus tag
    CELE_R05D3.2
    See related
    AllianceGenome:WB:WBGene00019877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including enteric muscle; hypodermis; intestine; nervous system; and vulval muscle. Used to study bone development disease. Human ortholog(s) of this gene implicated in Laurin-Sandrow syndrome; acheiropody; and syndactyly type 4. Orthologous to human LMBR1 (limb development membrane protein 1) and LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lmbr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (8372270..8375220)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Putative zinc finger protein R05D3.3 Neighboring gene ncRNA Neighboring gene Histone-lysine N-methyltransferase met-2 Neighboring gene DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans. Bai X, et al. Dis Model Mech, 2024 Jun 1. PMID 38454882, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LIMR family protein R05D3.2
    NP_001411903.1
    • Confirmed by transcript evidence
    NP_498847.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8372270..8375220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066446.7 → NP_498847.1  LIMR family protein R05D3.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34535
      Conserved Domains (1) summary
      pfam04791
      Location:74 → 693
      LMBR1; LMBR1-like membrane protein

    2. NM_001424973.1 → NP_001411903.1  LIMR family protein R05D3.2 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34535.1

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