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    T12G3.2 CULLIN_2 domain-containing protein;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T12G3.2
    Official Full Name
    CULLIN_2 domain-containing protein;Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00011738
    Locus tag
    CELE_T12G3.2
    See related
    AllianceGenome:WB:WBGene00011738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; defense response; and regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T12G3.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (12038985..12046857, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein mL51 Neighboring gene ZZ-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Strictosidine synthase conserved region domain-containing protein Neighboring gene Beta-1,3-galactosyltransferase bre-5;Hexosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CULLIN_2 domain-containing protein;Protein kinase domain-containing protein
    NP_001255611.1
    • Confirmed by transcript evidence
    NP_001294006.1
    • Confirmed by transcript evidence
    NP_001367238.1
    • Confirmed by transcript evidence
    NP_001368486.1
    • Confirmed by transcript evidence
    NP_001379103.1
    • Confirmed by transcript evidence
    NP_001379417.1
    • Confirmed by transcript evidence
    NP_001379418.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12038985..12046857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392407.1 → NP_001379103.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22435
      Conserved Domains (1) summary
      cl15255
      Location:605 → 704
      SH2; Src homology 2 (SH2) domain

    2. NM_001392405.1 → NP_001379418.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JLY9
      Conserved Domains (2) summary
      smart00818
      Location:829 → 893
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cl15255
      Location:605 → 704
      SH2; Src homology 2 (SH2) domain

    3. NM_001392406.1 → NP_001379417.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JLZ0
      Conserved Domains (1) summary
      cl15255
      Location:605 → 704
      SH2; Src homology 2 (SH2) domain

    4. NM_001380474.1 → NP_001368486.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD51
      Conserved Domains (2) summary
      smart00818
      Location:850 → 914
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cl15255
      Location:626 → 725
      SH2; Src homology 2 (SH2) domain

    5. NM_001380475.1 → NP_001367238.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT30
      Conserved Domains (1) summary
      cl15255
      Location:626 → 725
      SH2; Src homology 2 (SH2) domain

    6. NM_001307077.3 → NP_001294006.1  CULLIN_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294006.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AEA3
      Conserved Domains (1) summary
      cd09919
      Location:530 → 629
      SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family

    7. NM_001268682.3 → NP_001255611.1  CULLIN_2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT31
      Conserved Domains (1) summary
      cd09919
      Location:530 → 629
      SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
    Nucleotide Protein
    Heading Accession and Version

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