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    elpc-1 Elongator complex protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elpc-1
    Official Full Name
    Elongator complex protein 1
    Primary source
    WormBase:WBGene00022463
    Locus tag
    CELE_Y110A7A.16
    See related
    AllianceGenome:WB:WBGene00022463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA binding activity. Involved in several processes, including gene expression; olfactory learning; and vulval development. Located in cytoplasm; neuron projection; and neuronal cell body. Is expressed in several structures, including pharynx and vulva. Used to study Riley-Day syndrome. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elpc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (5114122..5118852, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene MARVEL domain-containing protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Cell division cycle protein 27 homolog Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitous RNA-dependent RNA polymerase and gene silencing. Birchler JA. Genome Biol, 2009. PMID 19951394, Free PMC Article
    2. The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. Solinger JA, et al. PLoS Genet, 2010 Jan 22. PMID 20107598, Free PMC Article
    3. Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. Chen C, et al. PLoS Genet, 2009 Jul. PMID 19593383, Free PMC Article
    4. Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. Pastore C, et al. J Biol Chem, 2012 Jan 13. PMID 22065580, Free PMC Article
    5. Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans. Fernandes De Abreu DA, et al. Front Cell Dev Biol, 2020. PMID 33195203, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elpc1 and elpc3 complex regulates neuronal alpha-tubulin acetylation.
      Title: The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator complex protein 1
    NP_001364720.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5114122..5118852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377580.2 → NP_001364720.1  Elongator complex protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N595
      Conserved Domains (1) summary
      cl27115
      Location:62 → 829
      IKI3; IKI3 family
    Nucleotide Protein
    Heading Accession and Version

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