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    ran-2 Ran GTPase-activating protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176115, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ran-2
    Official Full Name
    Ran GTPase-activating protein 2
    Primary source
    WormBase:WBGene00004303
    Locus tag
    CELE_C29E4.3
    See related
    AllianceGenome:WB:WBGene00004303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in intestinal cell. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ran-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (7933535..7937708)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nuclear pore complex protein 15 Neighboring gene ncRNA Neighboring gene Putative galactocerebrosidase Neighboring gene Protein FMC1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Bamba C, et al. Curr Biol, 2002 Mar 19. PMID 11909538
    2. Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Nahaboo W, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833711, Free PMC Article
    3. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Askjaer P, et al. Mol Biol Cell, 2002 Dec. PMID 12475958, Free PMC Article
    4. Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex. Burt EC, et al. Invert Neurosci, 2006 Dec. PMID 16964508
    5. Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis. Gönczy P, et al. J Cell Biol, 1999 Mar 8. PMID 10085292, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase-activating protein 2
    NP_741232.1
    • Confirmed by transcript evidence
    NP_741233.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7933535..7937708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171884.5 → NP_741233.2  Ran GTPase-activating protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741233.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34342, Q8MYR0, Q8TA79
      Conserved Domains (2) summary
      cd00116
      Location:49 → 370
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:478 → 508
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_171198.8 → NP_741232.1  Ran GTPase-activating protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34342
      Conserved Domains (2) summary
      cd00116
      Location:12 → 333
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:441 → 471
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34342.3

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