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    hyls-1 Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 179118, updated on 9-Dec-2024

    Summary

    Official Symbol
    hyls-1
    Official Full Name
    Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog
    Primary source
    WormBase:WBGene00015466
    Locus tag
    CELE_C05C8.9
    See related
    AllianceGenome:WB:WBGene00015466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cilium assembly and foraging behavior. Located in centriole and non-motile cilium. Is expressed in amphid neurons; inner labial neurons; and outer labial neurons. Used to study hydrolethalus syndrome. Human ortholog(s) of this gene implicated in hydrolethalus syndrome 1. Orthologous to human HYLS1 (HYLS1 centriolar and ciliogenesis associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hyls-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (7237381..7239659)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene KRR1 small subunit processome component Neighboring gene Exonuclease domain-containing protein Neighboring gene BTB/POZ domain-containing protein 9 Neighboring gene ATP synthase subunit s, mitochondrial Neighboring gene mannose-6-phosphate isomerase

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in foraging behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Centriolar and ciliogenesis-associated protein hyls-1;Hydrolethalus syndrome protein 1 homolog
    NP_001367430.1
    • Confirmed by transcript evidence
    NP_504840.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7237381..7239659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072439.7NP_504840.1  Centriolar and ciliogenesis-associated protein hyls-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504840.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95X94
      Conserved Domains (1) summary
      pfam15311
      Location:195250
      HYLS1_C; Hydrolethalus syndrome protein 1 C-terminus
    2. NM_001380690.2NP_001367430.1  Hydrolethalus syndrome protein 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYG1