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    ceeh-1 Epoxide hydrolase 1 [ Caenorhabditis elegans ]

    Gene ID: 175239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceeh-1
    Official Full Name
    Epoxide hydrolase 1
    Primary source
    WormBase:WBGene00019329
    Locus tag
    CELE_K02F3.6
    See related
    AllianceGenome:WB:WBGene00019329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables epoxide hydrolase activity. Involved in cellular lipid metabolic process. Predicted to be located in membrane. Orthologous to human EPHX3 (epoxide hydrolase 3) and EPHX4 (epoxide hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceeh-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (828593..832277, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dachshund homolog dac-1 Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. Harris TR, et al. Arch Biochem Biophys, 2008 Apr 15. PMID 18267101, Free PMC Article
    2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epoxide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Epoxide hydrolase 1
    NP_497268.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      828593..832277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064867.7 → NP_497268.1  Epoxide hydrolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBI4
      Conserved Domains (2) summary
      COG0596
      Location:119 → 400
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:128 → 257
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBI4.1

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