lag-1 Suppressor of hairless protein homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: lag-1
Official Full Name: Suppressor of hairless protein homolog
Primary source: WormBase:WBGene00002245
Locus tag: CELE_K08B4.1
See related: AllianceGenome:WB:WBGene00002245
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including dauer exit; germ cell development; and regulation of DNA-templated transcription. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including ADF; P4.p; P5.p; P6.p; and ventral uterine precursor. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to several human genes including RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See lag-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 12

Sequence:: Chromosome: IV; NC_003282.8 (6095407..6110655)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two classes of active transcription sites and their roles in developmental regulation.
Title: Two classes of active transcription sites and their roles in developmental regulation.
LIN-12 signaling is necessary for the suppression of lag-1 expression in the anchor cell in Caenorhabditis elegans.
Title: LIN-12/Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification.
Regulation of hlh-6 by LAG-1 is strictly negative: removal of HRL1 or LAG-1 regulation results in ectopic expression of hlh-6, but does not affect expression in pharyngeal glands.
Title: The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans.
2.85 A crystal structure of CSL ortholog Lag-1 with a target DNA
Title: Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

K08B4.1 (e-PCR)
- UniSTS:311466

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer exit	IGI Inferred from Genetic Interaction more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in stem cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Suppressor of hairless protein homolog

NP_001023278.1

Confirmed by transcript evidence

NP_001293740.1

Confirmed by transcript evidence

NP_001368385.1

Confirmed by transcript evidence

NP_741410.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6095407..6110655

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171350.7 → NP_741410.1 Suppressor of hairless protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741410.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDU7

Conserved Domains (3) summary

pfam09270
Location:384 → 536

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:217 → 379

LAG1-DNAbind; LAG1, DNA binding

cl15674
Location:558 → 660

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001028107.5 → NP_001023278.1 Suppressor of hairless protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023278.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MXE7

Conserved Domains (3) summary

pfam09270
Location:382 → 534

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:215 → 377

LAG1-DNAbind; LAG1, DNA binding

cl15674
Location:556 → 658

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001306811.4 → NP_001293740.1 Suppressor of hairless protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293740.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDU7, Q8MXE7, V6CK60, V6CLJ5

Conserved Domains (3) summary

pfam09270
Location:528 → 653

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:334 → 497

LAG1-DNAbind; LAG1, DNA binding

cl15674
Location:675 → 777

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_001380259.1 → NP_001368385.1 Suppressor of hairless protein homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam09270
Location:365 → 490

BTD; Beta-trefoil DNA-binding domain

pfam09271
Location:171 → 334

LAG1-DNAbind; LAG1, DNA binding

cl15674
Location:512 → 614

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...