dbl-1 Protein dbl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dbl-1
Official Full Name: Protein dbl-1
Primary source: WormBase:WBGene00000936
Locus tag: CELE_T25F10.2
See related: AllianceGenome:WB:WBGene00000936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Involved in several processes, including defense response to other organism; nematode male tail tip morphogenesis; and positive regulation of macromolecule metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in body wall musculature; nervous system; pm2 precursor; and in male. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); bone disease (multiple); cleft lip; hemochromatosis type 1; and orofacial cleft 11. Orthologous to several human genes including BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dbl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (6758135..6760418)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The DBL-1/TGF-beta signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans.
Title: The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans.
The authors provide evidence that DBL-1 signaling affects many molecular and cellular processes associated with body size and propose a model in which multiple body size factors are controlled by signaling through the DBL-1 pathway and by DBL-1-independent processes.
Title: Genetic interactions between the DBL-1/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans.
It has been concluded that Dbl-1 signaling regulates lipid metabolism in C. elegans through interorgan signaling to the Insulin pathway.
Title: Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling.
The dbl-1/TGF-beta and daf-12/NHR pathways have not previously been shown to affect L1 development, but disruption of these pathways delayed L1 development in fed larvae, consistent with these pathways promoting development in starved daf-16/FOXO mutants.
Title: dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest.
DBL-1, a TGF-beta, is essential for Caenorhabditis elegans aversive olfactory learning.
Title: DBL-1, a TGF-β, is essential for Caenorhabditis elegans aversive olfactory learning.
Data suggest that, for body size regulation, the site of expression of dbl-1 is less important than the level of expression.
Title: Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans.
DBL-1 regulates genes involved in physical structure, protein metabolism consistent with a role for DBL-1 in control of body size; up-regulation of genes involved in innate immunity, clarifying the role of DBL-1 in innate immunity.
Title: Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans.
This pathway regulates body size and male tail development.
Title: The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25F10.2 (e-PCR)
- UniSTS:311001

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables BMP receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Protein dbl-1

NP_504709.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6758135..6760418

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072308.8 → NP_504709.1 Protein dbl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504709.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEL5, O76514

Conserved Domains (2) summary

cd13761
Location:264 → 365

TGF_beta_BMP5_like; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins

cl02928
Location:120 → 182

TGFb_propeptide; TGF-beta propeptide