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    flp-2 SPREPIRF-amide [ Caenorhabditis elegans ]

    Gene ID: 181222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-2
    Official Full Name
    SPREPIRF-amide
    Primary source
    WormBase:WBGene00001445
    Locus tag
    CELE_W07E11.3
    See related
    AllianceGenome:WB:WBGene00001445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of protein secretion; and sleep. Acts upstream of with a positive effect on mitochondrial unfolded protein response. Is expressed in MC neuron; interneuron; and nerve ring. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (10094430..10095245, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene glutamate synthase (NADH) Neighboring gene FMRF-Like Peptide Neighboring gene TPLGTMRF-amide Neighboring gene ncRNA Neighboring gene Potassium channel domain-containing protein;Uncoordinated protein 58 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Shao LW, et al. Cell Res, 2016 Nov. PMID 27767096, Free PMC Article
    2. Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans. Mertens I, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809090
    3. Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast. Larsen MJ, et al. Int J Parasitol Drugs Drug Resist, 2013 Dec. PMID 24533288, Free PMC Article
    4. The Caenorhabditis elegans homeobox gene ceh-19 is required for MC motorneuron function. Feng H, et al. Genesis, 2013 Mar. PMID 23315936, Free PMC Article
    5. frpr-18, a neuropeptide receptor, regulates organismal lifespan and stress tolerance in C. elegans. Ouaakki H, et al. MicroPubl Biol, 2023. PMID 37383174, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SPREPIRF-amide
    NP_001024945.1
    • Confirmed by transcript evidence
    NP_001024946.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10094430..10095245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029775.3 → NP_001024946.1  SPREPIRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDZ1

    2. NM_001029774.4 → NP_001024945.1  SPREPIRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDZ1, G5EFN6
    Nucleotide Protein
    Heading Accession and Version

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