rege-1 Endoribonuclease rege-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rege-1
Official Full Name: Endoribonuclease rege-1
Primary source: WormBase:WBGene00016260
Locus tag: CELE_C30F12.1
See related: AllianceGenome:WB:WBGene00016260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including intestine; nervous system; pharynx; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to several human genes including ZC3H12A (zinc finger CCCH-type containing 12A); ZC3H12B (zinc finger CCCH-type containing 12B); and ZC3H12C (zinc finger CCCH-type containing 12C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rege-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (6954414..6961139, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans RNase, REGE-1, related to MCPIP1/Zc3h12a/Regnase-1, a key regulator of mammalian innate immunity, promotes accumulation of body fat.
Title: Ribonuclease-Mediated Control of Body Fat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10B11.9 (e-PCR)
- UniSTS:319636

C30F12.1 (e-PCR)
- UniSTS:313045

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Endoribonuclease rege-1

NP_491985.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6954414..6961139 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059584.8 → NP_491985.4 Endoribonuclease rege-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491985.4

Status: REVIEWED

UniProtKB/Swiss-Prot

G4S4L8, Q95YE2

Conserved Domains (1) summary

pfam11977
Location:224 → 377

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain