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    mai-1 ATPase inhibitor mai-1, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 3565232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mai-1
    Official Full Name
    ATPase inhibitor mai-1, mitochondrial
    Primary source
    WormBase:WBGene00003124
    Locus tag
    CELE_K10B3.9
    See related
    AllianceGenome:WB:WBGene00003124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATPase inhibitor activity. Predicted to be involved in negative regulation of ATP-dependent activity. Located in cytoplasm. Is expressed in several structures, including coelomocyte; cuticle; hypodermis; rectum; and vulva. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mai-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_003284.9 (3114692..3115578, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase 3 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase 2 Neighboring gene Spectrin alpha chain Neighboring gene Small EDRK-rich factor-like N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ATPase inhibitor factor 1 (IF1) MAI-2 preserves the mitochondrial membrane potential (Δψm) and is important to induce germ cell apoptosis. Fernández-Cárdenas LP, et al. PLoS One, 2017. PMID 28829773, Free PMC Article
    2. Caenorhabditis elegans MAI-1 protein, which is similar to mitochondrial ATPase inhibitor (IF1), can inhibit yeast F0F1-ATPase but cannot be transported to yeast mitochondria. Ichikawa N, et al. J Bioenerg Biomembr, 2006 Apr. PMID 16897438
    3. Interplay between AAUAAA and the trans-splice site in processing of a Caenorhabditis elegans operon pre-mRNA. Liu Y, et al. RNA, 2001 Feb. PMID 11233975, Free PMC Article
    4. Relationship between 3' end formation and SL2-specific trans-splicing in polycistronic Caenorhabditis elegans pre-mRNA processing. Kuersten S, et al. RNA, 1997 Mar. PMID 9056764, Free PMC Article
    5. Molecular genetics. Operons in eukaryotes follow the spliced leader. Hirsh D. Nature, 1994 Nov 17. PMID 7969465

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ATP-dependent activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATPase inhibitor mai-1, mitochondrial
    NP_508536.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3114692..3115578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076135.8 → NP_508536.1  ATPase inhibitor mai-1, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P37209
      Conserved Domains (1) summary
      pfam04568
      Location:20 → 68
      IATP; Mitochondrial ATPase inhibitor, IATP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37209.1

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