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    agmo-1 Alkylglycerol monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 176695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agmo-1
    Official Full Name
    Alkylglycerol monooxygenase
    Primary source
    WormBase:WBGene00007210
    Locus tag
    CELE_BE10.2
    See related
    AllianceGenome:WB:WBGene00007210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glyceryl-ether monooxygenase activity. Predicted to be involved in membrane lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See agmo-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (12793386..12798157, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Gamma-aminobutyric acid receptor subunit beta Neighboring gene Ligand-Gated ion Channel Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipodisqs for eukaryote lipidomics with retention of viability: Sensitivity and resistance to Leucobacter infection linked to C.elegans cuticle composition. Bada Juarez JF, et al. Chem Phys Lipids, 2019 Aug. PMID 31102583
    2. An enhanced C. elegans based platform for toxicity assessment. Xiong H, et al. Sci Rep, 2017 Aug 29. PMID 28852193, Free PMC Article
    3. Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4). Loer CM, et al. Genetics, 2015 May. PMID 25808955, Free PMC Article
    4. A lipid transfer protein ensures nematode cuticular impermeability. Njume FN, et al. iScience, 2022 Nov 18. PMID 36339267, Free PMC Article
    5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glyceryl-ether monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceryl-ether monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alkylglycerol monooxygenase
    NP_499664.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12793386..12798157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067263.9 → NP_499664.2  Alkylglycerol monooxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499664.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17554
      UniProtKB/TrEMBL
      A0A0H3W5B8
      Conserved Domains (2) summary
      COG3000
      Location:104 → 293
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:130 → 262
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17554.2

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