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    knl-3 Kinetochore NuLl [ Caenorhabditis elegans ]

    Gene ID: 178669, updated on 9-Dec-2024

    Summary

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    Official Symbol
    knl-3
    Official Full Name
    Kinetochore NuLl
    Primary source
    WormBase:WBGene00020392
    Locus tag
    CELE_T10B5.6
    See related
    AllianceGenome:WB:WBGene00020392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including chromosome organization; positive regulation of cell cycle process; and positive regulation of kinetochore assembly. Located in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See knl-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (1869213..1870558)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Small-subunit processome Utp12 domain-containing protein;Utp12 domain-containing protein Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene T-complex protein 1 subunit eta Neighboring gene Ig-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of kinetochore assembly and function in Caenorhabditis elegans embryos and human cells. Gassmann R, et al. Methods, 2007 Feb. PMID 17189860
    2. Chromosome segregation during female meiosis in C. elegans: A tale of pushing and pulling. Taylor SJP, et al. J Cell Biol, 2020 Dec 7. PMID 33211077, Free PMC Article
    3. Evidence for anaphase pulling forces during C. elegans meiosis. Danlasky BM, et al. J Cell Biol, 2020 Dec 7. PMID 33064834, Free PMC Article
    4. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Welburn JP, et al. Mol Cell, 2010 May 14. PMID 20471944, Free PMC Article
    5. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Gerson-Gurwitz A, et al. Cell, 2016 Apr 7. PMID 27020753, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kinetochore NuLl
    NP_503520.1
    • Product from WormBase gene class knl;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1869213..1870558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071119.9 → NP_503520.1  Kinetochore NuLl [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76406
    Nucleotide Protein
    Heading Accession and Version

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