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    gipc-1 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gipc-1
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00016440
    Locus tag
    CELE_C35D10.2
    See related
    AllianceGenome:WB:WBGene00016440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in intestine and spermatid. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 15 and oculopharyngodistal myopathy 2. Orthologous to several human genes including GIPC1 (GIPC PDZ domain containing family member 1) and GIPC3 (GIPC PDZ domain containing family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gipc-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (4870778..4872261)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene MSP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Methyltransferase type 11 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility. Kim J, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33280819
    2. Distinct roles of two myosins in C. elegans spermatid differentiation. Hu J, et al. PLoS Biol, 2019 Apr. PMID 30990821, Free PMC Article
    3. Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synuclein. Vartiainen S, et al. Neurobiol Dis, 2006 Jun. PMID 16626960
    4. Evaluating the adverse effects and mechanisms of nanomaterial exposure on longevity of C. elegans: A literature meta-analysis and bioinformatics analysis of multi-transcriptome data. Yin F, et al. Environ Res, 2024 Apr 15. PMID 38224941
    5. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Hamamichi S, et al. Proc Natl Acad Sci U S A, 2008 Jan 15. PMID 18182484, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility.
      Title: Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    PDZ domain-containing protein
    NP_498017.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4870778..4872261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065616.8 → NP_498017.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18488
      Conserved Domains (1) summary
      cd00992
      Location:138 → 218
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein
    Heading Accession and Version

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