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    Y48E1C.1 Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit [ Caenorhabditis elegans ]

    Gene ID: 174982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y48E1C.1
    Official Full Name
    Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit
    Primary source
    WormBase:WBGene00013014
    Locus tag
    CELE_Y48E1C.1
    See related
    AllianceGenome:WB:WBGene00013014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in replication fork processing and resolution of meiotic recombination intermediates. Predicted to be part of FANCM-MHF complex. Orthologous to human CENPS-CORT (CENPS-CORT readthrough) and CENPS (centromere protein S). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y48E1C.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (13415007..13424449)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transcription factor efl-2 Neighboring gene Threonylcarbamoyl-AMP synthase Neighboring gene Carnosine N-methyltransferase Neighboring gene SnoaL-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans. Harper NC, et al. Dev Cell, 2011 Nov 15. PMID 22018922, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FANCM-MHF complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Centromere protein S;Eukaryotic translation initiation factor 3 30 kDa subunit
    NP_001254386.1
    • Confirmed by transcript evidence
    NP_496828.1
    • Confirmed by transcript evidence
    NP_871968.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13415007..13424449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182168.5 → NP_871968.1  Eukaryotic translation initiation factor 3 30 kDa subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBR6

    2. NM_064427.7 → NP_496828.1  Centromere protein S [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC81
      Conserved Domains (2) summary
      pfam03342
      Location:219 → 321
      Rhabdo_M1; Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)
      pfam15630
      Location:37 → 119
      CENP-S; Kinetochore component CENP-S

    3. NM_001267457.3 → NP_001254386.1  Centromere protein S [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBV2
      Conserved Domains (2) summary
      pfam03342
      Location:154 → 256
      Rhabdo_M1; Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)
      pfam15630
      Location:14 → 54
      CENP-S; Kinetochore component CENP-S

    RNA

    1. NR_144482.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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