wapl-1 WAPL domain-containing protein;Wings apart-like protein homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wapl-1
Official Full Name: WAPL domain-containing protein;Wings apart-like protein homolog 1
Primary source: WormBase:WBGene00019953
Locus tag: CELE_R08C7.10
See related: AllianceGenome:WB:WBGene00019953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cohesin unloader activity. Involved in positive regulation of double-strand break repair via homologous recombination. Located in germ cell nucleus. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wapl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (4442362..4445740, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
Title: The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1.
Data show that condensin I binds to WAPL-1 and counteracts WAPL-1-dependent cohesin removal.
Title: Condensin I protects meiotic cohesin from WAPL-1 mediated removal.
WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion.
Title: Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R08C7.10 (e-PCR)
- UniSTS:312103

R08C7.3 (e-PCR)
- UniSTS:321020

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP-dependent protein-DNA unloader activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cohesin unloader activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WAPL domain-containing protein;Wings apart-like protein homolog 1

NP_001360111.1

Confirmed by transcript evidence

NP_001368333.1

Confirmed by transcript evidence

NP_001368334.1

Confirmed by transcript evidence

NP_500566.1

Confirmed by transcript evidence

NP_500567.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4442362..4445740 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068165.6 → NP_500566.1 Wings apart-like protein homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0H5

Conserved Domains (1) summary

pfam07814
Location:217 → 561

WAPL; Wings apart-like protein regulation of heterochromatin
NM_068166.8 → NP_500567.1 WAPL domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500567.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21843

Conserved Domains (1) summary

pfam07814
Location:215 → 559

WAPL; Wings apart-like protein regulation of heterochromatin
NM_001372798.2 → NP_001360111.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0H6

Conserved Domains (1) summary

pfam07814
Location:215 → 559

WAPL; Wings apart-like protein regulation of heterochromatin
NM_001380189.1 → NP_001368334.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PCH6

Conserved Domains (1) summary

cl00304
Location:18 → 95

TP_methylase; S-AdoMet-dependent tetrapyrrole methylases
NM_001380190.1 → NP_001368333.1 WAPL domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PC40

Conserved Domains (1) summary

pfam07814
Location:217 → 561

WAPL; Wings apart-like protein regulation of heterochromatin