csr-1 Piwi domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: csr-1
Official Full Name: Piwi domain-containing protein
Primary source: WormBase:WBGene00017641
Locus tag: CELE_F20D12.1
See related: AllianceGenome:WB:WBGene00017641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables endoribonuclease activity, cleaving siRNA-paired mRNA. Involved in P granule assembly; mitotic sister chromatid segregation; and siRNA-mediated gene silencing by mRNA destabilization. Located in P granule; condensed nuclear chromosome; and metaphase plate. Is expressed in several structures, including germ line; somatic cell; sperm; spermatid; and spermatocyte. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See csr-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (7957267..7962157)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog.
Title: Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog.
A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing.
Title: A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing.
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
Title: Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1.
Title: Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1.
Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.
Title: Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.
most highly expressed genes produce 22G-RNAs through a distinct pathway that presumably involves the Argonaute CSR-1.
Title: Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans.
targeting by the CSR-1 Argonaute correlates with reduced piRNA binding density and suppression of piRNA-associated secondary small RNAs.
Title: Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline.
CSR1 role in accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
Title: The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
Disruption of CSR-1 results in differential dauer-deficient phenotypes that are dependent upon the experienced environmental stress. CSR-1 is required for expression of a subset of G proteins with functions in the detection of pheromone components.
Title: Endogenous RNAi Pathways Are Required in Neurons for Dauer Formation in Caenorhabditis elegans.
The CSR-1 pathway helps maintain the directionality of active transcription, thereby propagating the distinction between transcriptionally active and silent genomic regions.
Title: Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F20D12.1 (e-PCR)
- UniSTS:309852

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endoribonuclease activity, cleaving siRNA-paired mRNA	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in P granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in metaphase plate	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Piwi domain-containing protein

NP_001040938.1

Confirmed by transcript evidence

NP_001040939.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7957267..7962157

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047473.4 → NP_001040938.1 Piwi domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040938.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZD5

Conserved Domains (2) summary

smart00949
Location:399 → 521

PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille

cd02826
Location:555 → 993

Piwi-like; PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component ...
NM_001047474.3 → NP_001040939.1 Piwi domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040939.1

Status: REVIEWED

UniProtKB/TrEMBL

Q27GU1

Conserved Domains (2) summary

smart00949
Location:236 → 358

PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille

cd02826
Location:392 → 830

Piwi-like; PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component ...