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    wshc-4 HEPN_LA2681 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wshc-4
    Official Full Name
    HEPN_LA2681 domain-containing protein
    Primary source
    WormBase:WBGene00013167
    Locus tag
    CELE_Y53F4B.21
    See related
    AllianceGenome:WB:WBGene00013167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in endosomal transport and endosome organization. Predicted to be part of WASH complex. Predicted to be active in endosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 43. Orthologous to human WASHC4 (WASH complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wshc-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (15090180..15109008)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Aminopeptidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Beta-lactamase-like protein 2 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HEPN_LA2681 domain-containing protein
    NP_497106.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15090180..15109008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064705.5 → NP_497106.3  HEPN_LA2681 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497106.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NA99
      Conserved Domains (3) summary
      pfam14744
      Location:586 → 945
      WASH-7_mid; WASH complex subunit 7
      pfam14745
      Location:53 → 499
      WASH-7_N; WASH complex subunit 7, N-terminal
      pfam14746
      Location:985 → 1123
      WASH-7_C; WASH complex subunit 7, C-terminal
    Nucleotide Protein
    Heading Accession and Version

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