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    dgtr-1 Acyltransferase [ Caenorhabditis elegans ]

    Gene ID: 189077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgtr-1
    Official Full Name
    Acyltransferase
    Primary source
    WormBase:WBGene00020910
    Locus tag
    CELE_W01A11.2
    See related
    AllianceGenome:WB:WBGene00020910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Located in sarcoplasmic reticulum. Is expressed in nervous system. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgtr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (6497108..6498484)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Galectin Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene Epoxide hydrolase;Microsomal epoxide hydrolase Neighboring gene molybdopterin molybdotransferase Neighboring gene DUF2382 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hierarchical assembly of the eggshell and permeability barrier in C. elegans. Olson SK, et al. J Cell Biol, 2012 Aug 20. PMID 22908315, Free PMC Article
    2. Identification and analysis of internal promoters in Caenorhabditis elegans operons. Huang P, et al. Genome Res, 2007 Oct. PMID 17712020, Free PMC Article
    3. High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. Hunt-Newbury R, et al. PLoS Biol, 2007 Sep. PMID 17850180, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Acyltransferase
    NP_504649.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6497108..6498484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072248.6 → NP_504649.1  Acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23067
      Conserved Domains (1) summary
      pfam03982
      Location:63 → 359
      DAGAT; Diacylglycerol acyltransferase
    Nucleotide Protein
    Heading Accession and Version

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