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    hcp-1 HoloCentric chromosome binding Protein [ Caenorhabditis elegans ]

    Gene ID: 179049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hcp-1
    Official Full Name
    HoloCentric chromosome binding Protein
    Primary source
    WormBase:WBGene00001829
    Locus tag
    CELE_ZK1055.1
    See related
    AllianceGenome:WB:WBGene00001829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including kinetochore assembly; nuclear chromosome segregation; and spindle organization. Located in kinetochore; nucleus; and spindle. Is expressed in AB; Psub1; and head. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hcp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (6594194..6599208)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene DUF4139 domain-containing protein;Protein F37C4.5;Transposase Neighboring gene Protein F37C4.5 Neighboring gene HAT C-terminal dimerization domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans. Moore LL, et al. J Cell Biol, 1999 Nov 1. PMID 10545493, Free PMC Article
    2. HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres. Moore LL, et al. J Cell Biol, 2001 Jun 11. PMID 11402064, Free PMC Article
    3. The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli. Stear JH, et al. Mol Biol Cell, 2004 Nov. PMID 15371539, Free PMC Article
    4. Functional midbody assembly in the absence of a central spindle. Hirsch SM, et al. J Cell Biol, 2022 Mar 7. PMID 34994802, Free PMC Article
    5. NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo. Simões PA, et al. J Cell Sci, 2018 Jan 8. PMID 29192061, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly.
      Title: Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly.
    2. The C. elegans NudE homolog NUD-2 is dispensable for dynein- and LIS-1-dependent mitotic spindle assembly in the zygote. This facilitates functional characterization of kinetochore-localized NUD-2, which is recruited by the CENP-F-like proteins HCP-1 and HCP-2 independently of RZZ-Spindly and dynein-LIS-1.
      Title: NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo.
    3. show that HCP-1 and HCP-2 recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the spindle assembly checkpoint components mutants
      Title: Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.
    4. The key role of HCP-1/2 is to target CLASP(CLS-2) to kinetochores to mediate chromosome segregation.
      Title: The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of meiotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HoloCentric chromosome binding Protein
    NP_504677.1
    • Product from WormBase gene class hcp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6594194..6599208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072276.4 → NP_504677.1  HoloCentric chromosome binding Protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76447
      Conserved Domains (1) summary
      pfam01576
      Location:322 → 1382
      Myosin_tail_1; Myosin tail
    Nucleotide Protein
    Heading Accession and Version

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