spds-1 PABS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spds-1
Official Full Name: PABS domain-containing protein
Primary source: WormBase:WBGene00012909
Locus tag: CELE_Y46G5A.19
See related: AllianceGenome:WB:WBGene00012909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable spermidine synthase activity. Predicted to be involved in spermidine biosynthetic process. Predicted to be active in cytosol. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spds-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (12806899..12810872)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y46G5.v (e-PCR)
- UniSTS:324335

Y46G5.w (e-PCR)
- UniSTS:324336

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables spermidine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables spermidine synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PABS domain-containing protein

NP_001366953.1

Confirmed by transcript evidence

NP_001367196.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12806899..12810872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381635.2 → NP_001366953.1 PABS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EFG3

Conserved Domains (1) summary

cl17173
Location:7 → 314

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001381634.1 → NP_001367196.1 PABS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B4E3X6

Conserved Domains (1) summary

cl17173
Location:7 → 366

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...