nfm-1 FERM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nfm-1
Official Full Name: FERM domain-containing protein
Primary source: WormBase:WBGene00003593
Locus tag: CELE_F42A10.2
See related: AllianceGenome:WB:WBGene00003593
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of early endosome to late endosome transport; positive regulation of protein localization to early endosome; and regulation of hippo signaling. Predicted to be located in several cellular components, including anchoring junction; cytoplasm; and cytoskeleton. Predicted to be active in several cellular components, including adherens junction; apical part of cell; and filopodium. Is expressed in several structures, including excretory gland cell; hypodermis; intestine; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nfm-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (6159453..6164589)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, we have delineated the conserved Hippo pathway in C. elegans consisting of NFM-1-WTS-1-YAP-1-EGL-44 and proved that the proper regulation of YAP-1 by upstream NFM-1 and WTS-1 is essential for maintenance of apicobasal membrane identities of the growing intestine
Title: The Hippo Pathway Is Essential for Maintenance of Apicobasal Polarity in the Growing Intestine of Caenorhabditis elegans.
NFM-1 is required nonautonomously, possibly in muscles, to promote Q lineage migrations. NFM-1 genetically interacts with SLT-1.
Title: The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42A10.2 (e-PCR)
- UniSTS:310268

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gliogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FERM domain-containing protein

NP_001022571.1

Confirmed by transcript evidence

NP_498335.1

Confirmed by transcript evidence

NP_498336.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6159453..6164589

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065934.5 → NP_498335.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498335.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYX2

Conserved Domains (5) summary

smart00295
Location:16 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 304

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam09606
Location:464 → 608

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00769
Location:339 → 432

ERM; Ezrin/radixin/moesin family

pfam15991
Location:320 → 526

G_path_suppress; G-protein pathway suppressor
NM_065935.5 → NP_498336.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498336.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYX3

Conserved Domains (5) summary

smart00295
Location:16 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 304

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam09606
Location:464 → 608

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00769
Location:339 → 432

ERM; Ezrin/radixin/moesin family

pfam15991
Location:320 → 526

G_path_suppress; G-protein pathway suppressor
NM_001027400.4 → NP_001022571.1 FERM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022571.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5LK46

Conserved Domains (5) summary

smart00295
Location:16 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 304

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam09606
Location:464 → 608

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00769
Location:339 → 432

ERM; Ezrin/radixin/moesin family

pfam15991
Location:320 → 526

G_path_suppress; G-protein pathway suppressor