dyb-1 Dystrobrevin-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dyb-1
Official Full Name: Dystrobrevin-1
Primary source: WormBase:WBGene00001115
Locus tag: CELE_F47G6.1
See related: AllianceGenome:WB:WBGene00001115
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables acetylcholine transmembrane transporter activity and cytoskeletal protein binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cholinergic synaptic transmission; and sarcomere organization. Located in plasma membrane. Part of dystrobrevin complex. Is expressed in several structures, including body wall musculature; dorsal nerve cord; intestinal cell; neurons; and non-striated muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to several human genes including DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dyb-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (1483083..1490498)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation
Title: Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels.
the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin complex
Title: Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle.
These observations revealed novel functions of dystrobrevin in controlling neurotransmitter release and muscle Ca(2+) transients by localizing the BK channel.
Title: Dystrobrevin controls neurotransmitter release and muscle Ca(2+) transients by localizing BK channels in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F47G6.1 (e-PCR)
- UniSTS:305971

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylcholine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in establishment of synaptic specificity at neuromuscular junction	TAS Traceable Author Statement more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signaling	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of dystrobrevin complex	IPI Inferred from Physical Interaction more info	PubMed
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Dystrobrevin-1

NP_001380163.1

Confirmed by transcript evidence

NP_001420389.1

Confirmed by transcript evidence

NP_490860.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1483083..1490498

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058459.7 → NP_490860.1 Dystrobrevin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490860.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TZI6, Q9Y048, W6RR09

Conserved Domains (3) summary

cd02334
Location:262 → 310

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:38 → 161

EF-hand_2; EF hand

pfam09069
Location:165 → 253

EF-hand_3; EF-hand
NM_001433452.1 → NP_001420389.1 Dystrobrevin-1 [Caenorhabditis elegans]

Status: REVIEWED
NM_001392953.1 → NP_001380163.1 Dystrobrevin-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

W6RY31