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    pes-1 Forkhead box protein pes-1 [ Caenorhabditis elegans ]

    Gene ID: 177267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pes-1
    Official Full Name
    Forkhead box protein pes-1
    Primary source
    WormBase:WBGene00003976
    Locus tag
    CELE_T28H11.4
    See related
    AllianceGenome:WB:WBGene00003976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryo development and nematode larval development. Located in cytoplasm and nucleus. Is expressed in several structures, including ABalpa; ABalpaa; body wall muscle cell from D lineage; neurons; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pes-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (5002748..5005486)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors. Hope IA. Development, 1994 Mar. PMID 8162851
    2. A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo. Azzaria M, et al. Dev Biol, 1996 Sep 15. PMID 8812130
    3. gon-2, a gene required for gonadogenesis in Caenorhabditis elegans. Sun AY, et al. Genetics, 1997 Nov. PMID 9383054, Free PMC Article
    4. Promoter trapping identifies real genes in C. elegans. Hope IA, et al. Mol Gen Genet, 1998 Nov. PMID 9862485
    5. Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues. Molin L, et al. Development, 2000 Nov. PMID 11044397

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Forkhead box protein pes-1
    NP_001023406.1
    • Confirmed by transcript evidence
    NP_001380128.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5002748..5005486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028235.3 → NP_001023406.1  Forkhead box protein pes-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGC9, Q7JMT8
      Conserved Domains (2) summary
      cd00059
      Location:93 → 168
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      TIGR00601
      Location:203 → 240
      rad23; UV excision repair protein Rad23

    2. NM_001392306.1 → NP_001380128.1  Forkhead box protein pes-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      TIGR00601
      Location:167 → 204
      rad23; UV excision repair protein Rad23
      pfam00250
      Location:57 → 132
      Forkhead; Forkhead domain
    Nucleotide Protein
    Heading Accession and Version

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