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    emb-30 Abnormal embryogenesis protein 30 [ Caenorhabditis elegans ]

    Gene ID: 176322, updated on 9-Dec-2024

    Summary

    Official Symbol
    emb-30
    Official Full Name
    Abnormal embryogenesis protein 30
    Primary source
    WormBase:WBGene00001284
    Locus tag
    CELE_F54C8.3
    See related
    AllianceGenome:WB:WBGene00001284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including anterior/posterior axis specification; asymmetric cell division; and metaphase/anaphase transition of meiosis I. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See emb-30 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (9435507..9441460, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Histone H3-like centromeric protein cpar-1 Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase F54C8.1 Neighboring gene TYR_PHOSPHATASE_2 domain-containing protein;putative tyrosine-protein phosphatase F54C8.4 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase/anaphase transition of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Abnormal embryogenesis protein 30
    NP_499074.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9435507..9441460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066673.8NP_499074.2  Abnormal embryogenesis protein 30 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499074.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34441, Q9U4A4
      Conserved Domains (2) summary
      sd00039
      Location:2470
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:26125
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain