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    C24H12.4 Helicase C-terminal domain-containing protein;RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 173432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C24H12.4
    Official Full Name
    Helicase C-terminal domain-containing protein;RNA helicase
    Primary source
    WormBase:WBGene00016073
    Locus tag
    CELE_C24H12.4
    See related
    AllianceGenome:WB:WBGene00016073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be active in nucleolus. Orthologous to human DDX56 (DEAD-box helicase 56). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C24H12.4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (411222..416629)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Downstream Neighbor of SoN homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Helicase C-terminal domain-containing protein;RNA helicase
    NP_001300515.1
    • Confirmed by transcript evidence
    NP_001300516.1
    • Partially confirmed by transcript evidence
    NP_740966.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      411222..416629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170970.7 → NP_740966.1  RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17157
      Conserved Domains (1) summary
      COG0513
      Location:46 → 561
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    2. NM_001313586.3 → NP_001300515.1  Helicase C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQY8
      Conserved Domains (1) summary
      cd18787
      Location:38 → 207
      SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

    3. NM_001313587.3 → NP_001300516.1  Helicase C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUI3
    Nucleotide Protein
    Heading Accession and Version

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