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    spon-1 Spondin-1 [ Caenorhabditis elegans ]

    Gene ID: 174169, updated on 9-Dec-2024

    Summary

    Official Symbol
    spon-1
    Official Full Name
    Spondin-1
    Primary source
    WormBase:WBGene00006893
    Locus tag
    CELE_F10E7.4
    See related
    AllianceGenome:WB:WBGene00006893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and serine-type endopeptidase inhibitor activity. Involved in axon development; cell adhesion mediated by integrin; and muscle attachment. Located in M band; basement membrane; and striated muscle dense body. Is expressed in basal lamina; body wall musculature; coelomocyte; excretory canal; and pharynx. Orthologous to human SPON1 (spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See spon-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (7116557..7120665)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ribosome assembly factor mrt4 Neighboring gene Uncharacterized protein Neighboring gene ZP domain-containing protein Neighboring gene ELM2 domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene pseudo

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion mediated by integrin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Spondin-1
    NP_495473.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7116557..7120665
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063072.8NP_495473.2  Spondin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495473.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19305
      Conserved Domains (4) summary
      smart00209
      Location:708759
      TSP1; Thrombospondin type 1 repeats
      cd08544
      Location:36171
      Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam00014
      Location:621672
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam06468
      Location:197381
      Spond_N; Spondin_N