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    rom-2 Inactive rhomboid-related protein 2 [ Caenorhabditis elegans ]

    Gene ID: 183564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rom-2
    Official Full Name
    Inactive rhomboid-related protein 2
    Primary source
    WormBase:WBGene00004401
    Locus tag
    CELE_C48B4.2
    See related
    AllianceGenome:WB:WBGene00004401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Orthologous to several human genes including RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rom-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (9593120..9595663, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative acyl-coenzyme A oxidase acox-1.5 Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. Dutt A, et al. PLoS Biol, 2004 Nov. PMID 15455032, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Inactive rhomboid-related protein 2
    NP_001366679.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9593120..9595663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379864.2 → NP_001366679.1  Inactive rhomboid-related protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34356
      Conserved Domains (2) summary
      pfam01694
      Location:165 → 311
      Rhomboid; Rhomboid family
      pfam13499
      Location:21 → 82
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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