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    • Showing Current items.

    htas-1 Histone H2A [ Caenorhabditis elegans ]

    Gene ID: 191549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    htas-1
    Official Full Name
    Histone H2A
    Primary source
    WormBase:WBGene00014240
    Locus tag
    CELE_ZK1251.1
    See related
    AllianceGenome:WB:WBGene00014240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in sperm and spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See htas-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (9682984..9683533, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Insulin-like peptide 7;putative insulin-like peptide beta-type 4 Neighboring gene ncRNA Neighboring gene 3-oxo-5-alpha-steroid 4-dehydrogenase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nematode histone H2A variant evolution reveals diverse histories of retention and loss and evidence for conserved core-like variant histone genes. Singh S, et al. PLoS One, 2024. PMID 38814971, Free PMC Article
    2. The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans. Samson M, et al. PLoS Genet, 2014 Oct. PMID 25299455, Free PMC Article
    3. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Murphy CT, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 18025456, Free PMC Article
    4. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone H2A variant HTAS-1 exclusively marks paternal chromatin.
      Title: The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H2A
    NP_501718.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9682984..9683533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069317.2 → NP_501718.1  Histone H2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23429
      Conserved Domains (2) summary
      smart00414
      Location:29 → 132
      H2A; Histone 2A
      cd00074
      Location:27 → 132
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
    Nucleotide Protein
    Heading Accession and Version

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