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    pdp-1 PPM-type phosphatase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdp-1
    Official Full Name
    PPM-type phosphatase domain-containing protein
    Primary source
    WormBase:WBGene00022832
    Locus tag
    CELE_ZK973.3
    See related
    AllianceGenome:WB:WBGene00022832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Predicted to be involved in signal transduction. Predicted to be active in mitochondrion. Is expressed in head muscle; head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) and PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4368089..4370463)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene BTB domain-containing protein Neighboring gene SS18 N-terminal domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Neighboring gene Chromo domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ketone bodies mimic the life span extending properties of caloric restriction. Veech RL, et al. IUBMB Life, 2017 May. PMID 28371201
    2. PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. Narasimhan SD, et al. PLoS Genet, 2011 Apr. PMID 21533078, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDP-1 modulates the expression of several insulin genes that are likely to feed into the IIS pathway to regulate DAF-16 activity.
      Title: PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PPM-type phosphatase domain-containing protein
    NP_491357.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4368089..4370463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058956.8 → NP_491357.1  PPM-type phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4M0
      Conserved Domains (1) summary
      cd00143
      Location:43 → 438
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version

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