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    • Showing Current items.

    eral-1 GTPase Era, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eral-1
    Official Full Name
    GTPase Era, mitochondrial
    Primary source
    WormBase:WBGene00008456
    Locus tag
    CELE_E02H1.2
    See related
    AllianceGenome:WB:WBGene00008456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Involved in positive regulation of egg-laying behavior and regulation of aerobic respiration. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eral-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (9588184..9589767, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1 Neighboring gene Putative UDP-glucuronosyltransferase ugt-58 Neighboring gene putative dimethyladenosine transferase Neighboring gene putative tRNA pseudouridine synthase tag-124

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome. Chatzispyrou IA, et al. Hum Mol Genet, 2017 Jul 1. PMID 28449065, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase Era, mitochondrial
    NP_496060.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9588184..9589767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063659.2 → NP_496060.1  GTPase Era, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09523
      Conserved Domains (2) summary
      cd04163
      Location:31 → 277
      Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
      COG1159
      Location:31 → 383
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09523.1

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