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    sptf-1 Specificity protein transcription factor 1 [ Caenorhabditis elegans ]

    Gene ID: 172909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sptf-1
    Official Full Name
    Specificity protein transcription factor 1
    Primary source
    WormBase:WBGene00009743
    Locus tag
    CELE_F45H11.1
    See related
    AllianceGenome:WB:WBGene00009743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and positive regulation of gene expression. Is expressed in several structures, including ASJ; intestinal cell; pharyngeal cell; rectal epithelial cell; and seam cell. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sptf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (10366621..10371697)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene Ubiquitin-like protein NEDD8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans. González-Barrios M, et al. Genetics, 2015 May. PMID 25769980, Free PMC Article
    2. A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes. Smith JJ, et al. Cell Rep, 2024 Mar 26. PMID 38421866, Free PMC Article
    3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Specificity protein transcription factor 1
    NP_001021465.1
    • Partially confirmed by transcript evidence
    NP_001359696.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10366621..10371697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373640.2 → NP_001359696.1  Specificity protein transcription factor 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      sd00019
      Location:262 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 284
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001026294.4 → NP_001021465.1  Specificity protein transcription factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q564X9, Q93727
      Conserved Domains (3) summary
      sd00019
      Location:262 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:260 → 284
      zf-C2H2; Zinc finger, C2H2 type
      cl41771
      Location:162 → 261
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93727.2

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