glp-1 glp-1/Notch intracellular domain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glp-1
Official Full Name: glp-1/Notch intracellular domain
Primary source: WormBase:WBGene00001609
Locus tag: CELE_F02A9.6
See related: AllianceGenome:WB:WBGene00001609
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coactivator activity. Involved in several processes, including chordate pharyngeal muscle development; positive regulation of cell population proliferation; and regulation of gene expression. Located in cytoplasm; endomembrane system; and lateral plasma membrane. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including AB lineage cell; anus; germ line; neurons; and somatic nervous system. Used to study cancer and obesity. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; Alagille syndrome; CADASIL 1; Hajdu-Cheney syndrome; and autoimmune disease (multiple). Orthologous to several human genes including NOTCH1 (notch receptor 1); NOTCH2 (notch receptor 2); and NOTCH3 (notch receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See glp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (9092241..9099698)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.
Title: A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.
A somatic proteoglycan controls Notch-directed germ cell fate.
Title: A somatic proteoglycan controls Notch-directed germ cell fate.
A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.
Title: A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.
Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans.
Title: Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans.
The findings suggest that the subunits of the DNA polymerase alpha-primase complex exhibit both discrete and shared functions in GLP-1/Notch or PUF-mediated germ cell dynamics in C. elegans.
Title: Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.
These results provide the first experimental evidence of an essential role for HSP90 in Notch signaling in development.
Title: The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans.
Molecular and genetic analyses indicate that the loss of ubr-5 function suppresses defects caused by reduced signaling via GLP-1 or LIN-12.
Title: UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.
The authors find that Notch-dependent active transcription sites occur in a probabilistic fashion and, unexpectedly, do so in a steep gradient across the stem cell pool.
Title: C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool.
Zygotically expressed MOM-2 (Wnt) is responsible for two distinct cell-cell interactions as the MS blastomere produces one-third of the body wall muscles. Both the inhibitory and the activating interactions require precise spatiotemporal expression of zygotic MOM-2, which is dependent upon two distinct GLP-1 Notch signals.
Title: Reciprocal signaling by Wnt and Notch specifies a muscle precursor in the C. elegans embryo.
Study suggests that GLP-1 signaling is directly responsible for driving all stages of proliferation in the wild-type germline, and loss of its activity causes differentiation without intervening, distinctly regulated transit-amplifying divisions.
Title: Analysis of Germline Stem Cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegans.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F02A9.6 (e-PCR)
- UniSTS:321336

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IC Inferred by Curator more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chordate pharyngeal muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chordate pharyngeal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic streaming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental growth	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of dauer	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glp-1/Notch intracellular domain

NP_499014.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9092241..9099698

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066613.5 → NP_499014.1 glp-1/Notch intracellular domain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499014.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13508

Conserved Domains (9) summary

smart00004
Location:489 → 526

NL; Domain found in Notch and Lin-12

cd00054
Location:232 → 269

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:956 → 1127

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:533 → 568

Notch; LNR domain

pfam06816
Location:612 → 661

NOD; NOTCH protein

pfam07684
Location:698 → 755

NODP; NOTCH protein

pfam12796
Location:999 → 1105

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:949 → 1002

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:961 → 992

ANK; ANK repeat [structural motif]