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    acbp-3 Acyl-CoA-binding protein homolog 3 [ Caenorhabditis elegans ]

    Gene ID: 181281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acbp-3
    Official Full Name
    Acyl-CoA-binding protein homolog 3
    Primary source
    WormBase:WBGene00009818
    Locus tag
    CELE_F47B10.7
    See related
    AllianceGenome:WB:WBGene00009818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Involved in lipid storage. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; and pharynx. Human ortholog(s) of this gene implicated in retinal dystrophy with leukodystrophy. Orthologous to human ACBD4 (acyl-CoA binding domain containing 4) and ACBD5 (acyl-CoA binding domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acbp-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (10903272..10905088)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Males induce premature demise of the opposite sex by multifaceted strategies. Booth LN, et al. Nat Aging, 2022 Sep. PMID 37118502, Free PMC Article
    2. Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans. Elle IC, et al. Biochem J, 2011 Jul 15. PMID 21539519
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA-binding protein homolog 3
    NP_509822.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10903272..10905088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077421.7 → NP_509822.2  Acyl-CoA-binding protein homolog 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509822.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20507
      Conserved Domains (1) summary
      cd00435
      Location:3 → 91
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20507.2

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