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    nduf-2.2 Complex I-49kD [ Caenorhabditis elegans ]

    Gene ID: 188912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nduf-2.2
    Official Full Name
    Complex I-49kD
    Primary source
    WormBase:WBGene00006463
    Locus tag
    CELE_T26A5.3
    See related
    AllianceGenome:WB:WBGene00006463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nduf-2.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (6465222..6467206)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dynein light chain 1, cytoplasmic Neighboring gene ncRNA Neighboring gene ANK_REP_REGION domain-containing protein;DUF223 domain-containing protein;DUF3668 domain-containing protein Neighboring gene ABC transporter domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. Kayser EB, et al. J Biol Chem, 2001 Jun 8. PMID 11278828
    2. CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Meisel JD, et al. Curr Biol, 2024 Jun 17. PMID 38810637, Free PMC Article
    3. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Kayser EB, et al. Mech Ageing Dev, 2004 Jun. PMID 15178135
    4. A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans. Knowlton WM, et al. Front Neurosci, 2017. PMID 28539870, Free PMC Article
    5. The role of mitochondria in the life of the nematode, Caenorhabditis elegans. Tsang WY, et al. Biochim Biophys Acta, 2003 Jul 14. PMID 12853115

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Complex I-49kD
    NP_498423.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6465222..6467206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066022.7 → NP_498423.1  Complex I-49kD [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22800
      Conserved Domains (1) summary
      PRK06075
      Location:85 → 474
      PRK06075; NADH-quinone oxidoreductase subunit D
    Nucleotide Protein
    Heading Accession and Version

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