mtrr-1 Methionine synthase reductase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtrr-1
Official Full Name: Methionine synthase reductase
Primary source: WormBase:WBGene00006510
Locus tag: CELE_C01G6.6
See related: AllianceGenome:WB:WBGene00006510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable FMN binding activity; [methionine synthase] reductase (NADPH) activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); and homocystinuria. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtrr-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (9285975..9289132)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C01G6.6 (e-PCR)
- UniSTS:308876

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	IEA Inferred from Electronic Annotation more info
enables [methionine synthase] reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables [methionine synthase] reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in homocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Methionine synthase reductase

NP_495978.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9285975..9289132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063577.7 → NP_495978.1 Methionine synthase reductase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495978.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17574, Q8I4N2

Conserved Domains (3) summary

cd06203
Location:287 → 681

methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...

COG0369
Location:5 → 681

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:6 → 142

Flavodoxin_1; Flavodoxin