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    mom-4 Mitogen-activated protein kinase kinase kinase mom-4 [ Caenorhabditis elegans ]

    Gene ID: 172842, updated on 9-Dec-2024

    Summary

    Official Symbol
    mom-4
    Official Full Name
    Mitogen-activated protein kinase kinase kinase mom-4
    Primary source
    WormBase:WBGene00003396
    Locus tag
    CELE_F52F12.3
    See related
    AllianceGenome:WB:WBGene00003396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables MAP kinase kinase kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; cell fate specification; and embryonic digestive tract morphogenesis. Located in striated muscle dense body. Is expressed in BAGL and BAGR. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mom-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (9895692..9900817, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Zinc finger protein ztf-11 Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables MAP kinase kinase kinase activity PubMed 
    enables MAP kinase kinase kinase activity  
    enables magnesium ion binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in striated muscle dense body PubMed 

    General protein information

    Preferred Names
    Mitogen-activated protein kinase kinase kinase mom-4
    NP_492620.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9895692..9900817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060219.10 → NP_492620.1  Mitogen-activated protein kinase kinase kinase mom-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTC6
      Conserved Domains (2) summary
      smart00220
      Location:57 → 301
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:57 → 303
      PKc_like; Protein Kinases, catalytic domain
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