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    wdr-46 WD repeat-containing protein 46 [ Caenorhabditis elegans ]

    Gene ID: 178185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr-46
    Official Full Name
    WD repeat-containing protein 46
    Primary source
    WormBase:WBGene00009211
    Locus tag
    CELE_F28D1.1
    See related
    AllianceGenome:WB:WBGene00009211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in body wall musculature; germ line; head; hypodermis; and intestine. Orthologous to human WDR46 (WD repeat domain 46). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wdr-46 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (12372253..12374834)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glutathione S-transferase Neighboring gene poly(A)-specific ribonuclease Neighboring gene ncRNA Neighboring gene Protein atz-1 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Pathogenesis-related protein 5-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1. Leung CK, et al. Free Radic Biol Med, 2012 Mar 1. PMID 22240150
    2. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
    3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR-46 is expressed in the nucleoli of multiple tissues in C. elegans and is required for rRNA processing.
      Title: Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 46
    NP_502358.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12372253..12374834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069957.8 → NP_502358.1  WD repeat-containing protein 46 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19873
      Conserved Domains (3) summary
      smart01033
      Location:409 → 487
      BING4CT; BING4CT (NUC141) domain
      sd00039
      Location:213 → 250
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:161 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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