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    lars-2 leucine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 172499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lars-2
    Official Full Name
    leucine--tRNA ligase
    Primary source
    WormBase:WBGene00003074
    Locus tag
    CELE_ZK524.3
    See related
    AllianceGenome:WB:WBGene00003074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in body wall musculature; intestine; and neurons. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lars-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (7457152..7460756, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phorbol ester/diacylglycerol-binding protein unc-13;Protein kinase C Neighboring gene Presenilin spe-4 Neighboring gene Protein kinase domain-containing protein Neighboring gene SERTA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome. Pierce SB, et al. Am J Hum Genet, 2013 Apr 4. PMID 23541342, Free PMC Article
    2. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Lee SS, et al. Nat Genet, 2003 Jan. PMID 12447374
    3. Mitochondrial genetics. Lemire B. WormBook, 2005 Sep 14. PMID 18023115, Free PMC Article
    4. Ageing and oxidants in the nematode Caenorhabditis elegans. Gems D. SEB Exp Biol Ser, 2009. PMID 19418991
    5. A systematic RNAi screen for longevity genes in C. elegans. Hamilton B, et al. Genes Dev, 2005 Jul 1. PMID 15998808, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine--tRNA ligase
    NP_001021875.1
    • Confirmed by transcript evidence
    NP_001129803.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7457152..7460756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026704.6 → NP_001021875.1  leucine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBH2, Q23511
      Conserved Domains (1) summary
      TIGR00396
      Location:29 → 747
      leuS_bact; leucyl-tRNA synthetase, eubacterial and mitochondrial family

    2. NM_001136331.4 → NP_001129803.1  leucine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3WFV4
      Conserved Domains (1) summary
      TIGR00396
      Location:1 → 343
      leuS_bact; leucyl-tRNA synthetase, eubacterial and mitochondrial family
    Nucleotide Protein
    Heading Accession and Version

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