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    impt-1 Protein IMPACT homolog [ Caenorhabditis elegans ]

    Gene ID: 173001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    impt-1
    Official Full Name
    Protein IMPACT homolog
    Primary source
    WormBase:WBGene00013122
    Locus tag
    CELE_Y52B11A.2
    See related
    AllianceGenome:WB:WBGene00013122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein sequestering activity. Predicted to be involved in GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of cytoplasmic translational initiation in response to stress. Predicted to be active in cytoplasm. Is expressed in intestine. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See impt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (10966325..10970177, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene cytochrome-b5 reductase Neighboring gene GTP-binding protein GEM Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. Ferraz RC, et al. BMC Biol, 2016 Oct 7. PMID 27717342, Free PMC Article
    2. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytoplasmic translational initiation in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein IMPACT homolog
    NP_001021782.1
    • Confirmed by transcript evidence
    NP_001379419.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10966325..10970177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026611.4 → NP_001021782.1  Protein IMPACT homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K779, Q9XWF4
      Conserved Domains (2) summary
      smart00591
      Location:10 → 102
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:138 → 247
      UPF0029; Uncharacterized protein family UPF0029

    2. NM_001392943.1 → NP_001379419.1  Protein IMPACT homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00591
      Location:10 → 100
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWF4.1

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