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    hmg-3 FACT complex subunit ssrp1-B [ Caenorhabditis elegans ]

    Gene ID: 172250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hmg-3
    Official Full Name
    FACT complex subunit ssrp1-B
    Primary source
    WormBase:WBGene00001973
    Locus tag
    CELE_C32F10.5
    See related
    AllianceGenome:WB:WBGene00001973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Involved in nematode pharynx development and regulation of embryonic development. Located in nucleus. Is expressed in germ line and gonad. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hmg-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5815609..5818132, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 51 homolog Neighboring gene Retinoblastoma-like protein homolog lin-35 Neighboring gene Uncharacterized protein Neighboring gene Nuclear hormone receptor family member nhr-2 Neighboring gene alanine transaminase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans. Suggs BZ, et al. Dev Biol, 2018 Dec 15. PMID 30336114, Free PMC Article
    2. Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network. Lei H, et al. Development, 2009 Apr. PMID 19261701, Free PMC Article
    3. HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity. Sural S, et al. Sci Adv, 2020 Oct. PMID 33087356, Free PMC Article
    4. CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Sonneville R, et al. Nat Cell Biol, 2017 May. PMID 28368371, Free PMC Article
    5. The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. Baugh LR, et al. Development, 2005 Apr. PMID 15772128

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode pharynx development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit ssrp1-B
    NP_491688.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5815609..5818132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059287.4 → NP_491688.1  FACT complex subunit ssrp1-B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491688.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01683
      Conserved Domains (4) summary
      COG5165
      Location:20 → 497
      POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
      cd01390
      Location:561 → 624
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      cd13231
      Location:332 → 429
      PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
      pfam03531
      Location:75 → 285
      SSrecog; Structure-specific recognition protein (SSRP1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01683.1

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