hmt-1 Heavy metal tolerance factor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmt-1
Official Full Name: Heavy metal tolerance factor 1
Primary source: WormBase:WBGene00001815
Locus tag: CELE_W09D6.6
See related: AllianceGenome:WB:WBGene00001815
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cadmium ion transmembrane transporter activity. Involved in cadmium ion transmembrane transport; cellular detoxification of cadmium ion; and detoxification of copper ion. Located in endosome and vacuolar membrane. Is expressed in coelomocyte; head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmt-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (11091548..11099964, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification in Schizosaccharomyces pombe and Caenorhabditis elegans.
Title: The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.
The N-terminal extension domain HMT-1 is required for protein-protein interactions and function..
Title: The N-terminal extension domain of the C. elegans half-molecule ABC transporter, HMT-1, is required for protein-protein interactions and function.
a half-molecule ABC transporter, HMT-1, detoxifies multiple heavy metals with coelomocytes of Caenorhabditis elegans
Title: Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans.
requirement for PC synthase for heavy metal tolerance in C. elegans demonstrate PC-dependent, HMT-1-mediated heavy metal detoxification
Title: CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09D6.6 (e-PCR)
- UniSTS:319724

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type heme transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification of cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in detoxification of cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of copper ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detoxification of copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in heme transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Heavy metal tolerance factor 1

NP_001022812.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11091548..11099964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027641.4 → NP_001022812.1 Heavy metal tolerance factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022812.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFD4

UniProtKB/TrEMBL

Q71JP7

Conserved Domains (1) summary

COG5265
Location:289 → 782

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]