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    oxi-1 HECT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oxi-1
    Official Full Name
    HECT domain-containing protein
    Primary source
    WormBase:WBGene00003898
    Locus tag
    CELE_Y39A1C.2
    See related
    AllianceGenome:WB:WBGene00003898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Human ortholog(s) of this gene implicated in Kaufman oculocerebrofacial syndrome. Orthologous to human UBE3B (ubiquitin protein ligase E3B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See oxi-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (10858284..10866946)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene beta-N-acetylhexosaminidase Neighboring gene Transmembrane inner ear Neighboring gene CSD domain-containing protein Neighboring gene Vps54_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the oxidative stress-responsive genes in Caenorhabditis elegans. Yanase S, et al. J Radiat Res, 1999 Mar. PMID 10408176
    2. oxi-1 and fshr-1 are required for neuromuscular signaling under normal and oxidative stress conditions in C. elegans. Wei B, et al. MicroPubl Biol, 2018 Aug 28. PMID 32550383, Free PMC Article
    3. Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome. Basel-Vanagaite L, et al. Am J Hum Genet, 2012 Dec 7. PMID 23200864, Free PMC Article
    4. Impacts of chronic low-level nicotine exposure on Caenorhabditis elegans reproduction: identification of novel gene targets. Smith MA Jr, et al. Reprod Toxicol, 2013 Sep. PMID 23735997, Free PMC Article
    5. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Mehta R, et al. Science, 2009 May 29. PMID 19372390, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HECT domain-containing protein
    NP_499392.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10858284..10866946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066991.6 → NP_499392.1  HECT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXE6
      Conserved Domains (1) summary
      cd00078
      Location:684 → 1064
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
    Heading Accession and Version

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