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    col-12 Cuticle collagen 12 [ Caenorhabditis elegans ]

    Gene ID: 179453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    col-12
    Official Full Name
    Cuticle collagen 12
    Primary source
    WormBase:WBGene00000601
    Locus tag
    CELE_F15H10.1
    See related
    AllianceGenome:WB:WBGene00000601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See col-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (10423898..10425198, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene Cuticle collagen 13 Neighboring gene Anaphase-promoting complex subunit 10 Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of the Caenorhabditis elegans cuticle collagen gene col-12 in Caenorhabditis briggsae. Gilleard JS, et al. Gene, 1997 Jul 9. PMID 9256075
    2. Conversion of a trans-spliced C. elegans gene into a conventional gene by introduction of a splice donor site. Conrad R, et al. EMBO J, 1993 Mar. PMID 8458337, Free PMC Article
    3. Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing. Park YS, et al. J Mol Biol, 1990 Jan 20. PMID 1689778
    4. Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Thein MC, et al. J Biol Chem, 2009 Jun 26. PMID 19406744, Free PMC Article
    5. Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion. Roberts B, et al. Mol Biol Cell, 2003 Nov. PMID 14551256, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cuticle collagen 12
    NP_505678.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10423898..10425198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073277.6 → NP_505678.1  Cuticle collagen 12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20630
      Conserved Domains (1) summary
      smart01088
      Location:17 → 69
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20630.1

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