aipl-1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: aipl-1
Official Full Name: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
Primary source: WormBase:WBGene00010685
Locus tag: CELE_K08F9.2
See related: AllianceGenome:WB:WBGene00010685
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in actin filament organization and regulation of protein localization. Predicted to be active in cortical actin cytoskeleton. Is expressed in body wall musculature; intestine; neurons; and spermatheca. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aipl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (15134198..15136801, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.
Title: WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.
H60K mutation of AIP1 partially impairs its pH sensitivity, suggesting that His-60 is involved in the pH sensor for AIP1.
Title: Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08F9.2 (e-PCR)
- UniSTS:321573

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein

NP_506733.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

15134198..15136801 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074332.5 → NP_506733.1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506733.1

Status: REVIEWED

UniProtKB/TrEMBL

O17939

Conserved Domains (3) summary

cd00200
Location:55 → 388

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:63 → 101

7WD40; WD40 repeat [structural motif]

cl29593
Location:236 → 597

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...