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    icl-1 Malate synthase [ Caenorhabditis elegans ]

    Gene ID: 178583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icl-1
    Official Full Name
    Malate synthase
    Primary source
    WormBase:WBGene00001564
    Locus tag
    CELE_C05E4.9
    See related
    AllianceGenome:WB:WBGene00001564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable isocitrate lyase activity and malate synthase activity. Involved in determination of adult lifespan. Located in mitochondrion. Is expressed in hypodermal cell; intestine; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See icl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (724332..728004, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene G protein-coupled receptor;Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class J

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response. Wang G, et al. Free Radic Biol Med, 2023 Nov 1. PMID 37758122
    2. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Gonzalez-Hunt CP, et al. Toxicology, 2021 Jan 15. PMID 33188857, Free PMC Article
    3. Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. Gallo M, et al. Mech Ageing Dev, 2011 Oct. PMID 21884719
    4. Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility. Woodhouse RM, et al. iScience, 2022 Dec 22. PMID 36465130, Free PMC Article
    5. Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Zuryn S, et al. Mech Ageing Dev, 2010 Sep. PMID 20688098

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response.
      Title: The glyoxylate shunt protein ICL-1 protects from mitochondrial superoxide stress through activation of the mitochondrial unfolded protein response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Malate synthase
    NP_001021367.1
    • Confirmed by transcript evidence
    NP_503306.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      724332..728004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026196.7 → NP_001021367.1  Malate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10663
      Conserved Domains (2) summary
      PRK15063
      Location:15 → 431
      PRK15063; isocitrate lyase; Provisional
      cd00727
      Location:456 → 860
      malate_synt_A; Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to ...

    2. NM_070905.7 → NP_503306.1  Malate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17353, Q10663, Q8IA71
      Conserved Domains (2) summary
      PRK15063
      Location:15 → 431
      PRK15063; isocitrate lyase; Provisional
      cd00727
      Location:456 → 964
      malate_synt_A; Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10663.2

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