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    spat-1 Protein aurora borealis [ Caenorhabditis elegans ]

    Gene ID: 175113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spat-1
    Official Full Name
    Protein aurora borealis
    Primary source
    WormBase:WBGene00010198
    Locus tag
    CELE_F57C2.6
    See related
    AllianceGenome:WB:WBGene00010198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase binding activity. Involved in positive regulation of mitotic cell cycle. Located in cytoplasm; kinetochore; and nucleus. Is expressed in EMS and P2. Orthologous to human BORA (BORA aurora kinase A activator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spat-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (14528752..14534174)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Toxin Neighboring gene Strictosidine synthase conserved region domain-containing protein Neighboring gene Multifunctional methyltransferase subunit TRM112-like protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Neuropeptide-Like Protein;Toxin Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Tavernier N, et al. Cell Cycle, 2015 Aug 3. PMID 26038951, Free PMC Article
    2. Mitotic entry: The interplay between Cdk1, Plk1 and Bora. Parrilla A, et al. Cell Cycle, 2016 Dec. PMID 27831827, Free PMC Article
    3. SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression. Noatynska A, et al. Development, 2010 Oct. PMID 20823068
    4. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, et al. Dev Cell, 2017 Oct 23. PMID 29065307, Free PMC Article
    5. Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. Tavernier N, et al. J Cell Biol, 2015 Mar 16. PMID 25753036, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.
      Title: Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.
    2. CDK-1 activates PLK-1 via SPAT-1 phosphorylation to promote entry into mitosis.
      Title: Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.
    3. SPAT-1 and PLK-1 depletion causes impaired polarity with abnormal length of the anterior and posterior PAR domains, and partial plk-1(RNAi) or spat-1(RNAi), but not air-1(RNAi), can rescue the lethality of a par-2 mutant.
      Title: SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein aurora borealis
    NP_001254433.1
    • Confirmed by transcript evidence
    NP_001254434.1
    • Confirmed by transcript evidence
    NP_001293534.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14528752..14534174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267504.3 → NP_001254433.1  Protein aurora borealis [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLK2
      Conserved Domains (1) summary
      pfam15280
      Location:84 → 327
      BORA_N; Protein aurora borealis N-terminus

    2. NM_001267505.2 → NP_001254434.1  Protein aurora borealis [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECT7
      Conserved Domains (1) summary
      pfam15280
      Location:84 → 325
      BORA_N; Protein aurora borealis N-terminus

    3. NM_001306605.1 → NP_001293534.1  Protein aurora borealis [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB03
    Nucleotide Protein
    Heading Accession and Version

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