crml-1 CARMIL pleckstrin homology domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crml-1
Official Full Name: CARMIL pleckstrin homology domain-containing protein
Primary source: WormBase:WBGene00010641
Locus tag: CELE_K07G5.1
See related: AllianceGenome:WB:WBGene00010641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activating protein binding activity. Involved in several processes, including axon guidance; negative regulation of Rac protein signal transduction; and regulation of axon extension involved in axon guidance. Located in plasma membrane. Is expressed in several structures, including distal tip cell; epithelial cell; excretory canal; neurons; and rectal epithelium. Human ortholog(s) of this gene implicated in immunodeficiency 58. Orthologous to human CARMIL1 (capping protein regulator and myosin 1 linker 1); CARMIL2 (capping protein regulator and myosin 1 linker 2); and CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See crml-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (7152462..7156786, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC-73, the C. elegans ortholog of Trio, is a guanine nucleotide exchange factor (GEF) upstream of both CED-10 and MIG-2 that is suppressed by CMRL1
Title: Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.
propose a role for CRML-1 as a novel regulator of cell and axon migrations that acts through inhibition of Rac signaling
Title: C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07G5.1 (e-PCR)
- UniSTS:307783

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CARMIL pleckstrin homology domain-containing protein

NP_001309450.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7152462..7156786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322686.4 → NP_001309450.1 CARMIL pleckstrin homology domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q21301

Conserved Domains (3) summary

sd00033
Location:282 → 310

LRR_RI; leucine-rich repeat [structural motif]

pfam17888
Location:31 → 128

Carm_PH; Carmil pleckstrin homology domain

cl39015
Location:281 → 606

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...